Naleo

NALEO™ SPECTRUM is a nutritional supplement that maintains and supports brain health.

NALEO™ SPECTRUM contains 32 essential vitamins, minerals and other nutrients that enhance and support brain health and contributes to normal growth and development.

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Ingredients and their Benefits:

Vitamin A contributes to the maintenance of eyesight, skin, membranes, and immune function, contributes the development and maintenance of night vision, and contributes to the development and maintenance of bones and teeth.

Vitamin B₁ and B₃ helps to metabolise carbohydrates, fats, and proteins, and contributes to normal growth and development.

Vitamin B₂, B₅ and B₆ helps to metabolise carbohydrates, fats and proteins and contributes to tissue formation.

Vitamin B₁₂ helps to metabolise carbohydrates, fats, and proteins, and contributes to normal red blood cell formation.

Vitamin C helps to metabolise fats and proteins, helps in the development and maintenance of bones, cartilage, teeth and gums, helps in connective tissue formation, and helps in wound healing. An antioxidant for the maintenance of good health.

Vitamin D helps in the development and maintenance of bones and teeth and helps in the absorption and use of calcium and phosphorous.

Vitamin E is an antioxidant for the maintenance of good health.

Vitamin H (Biotin) helps to metabolise carbohydrates, fats, and proteins.

Vitamin K₁ and K₂ contributes to the maintenance of normal bones.

Acetyl-L-Carnitine helps to support and maintain healthy brain function.

N-Acetyl-L-Cysteine (NAC) is a source of amino acids involved in muscle protein synthesis.

Calcium contributes to the development and maintenance of bones and teeth.

Choline helps to support liver function.

Chromium provides support for healthy glucose metabolism and helps the body to metabolise carbohydrates and fats.

Coenzyme Q-10 is an antioxidant that contributes to the protection of cells from oxidative stress and helps to maintain and support cardiovascular health.

Folate helps the body to metabolise proteins and helps to form red blood cells.

Iodine contributes to the normal production of the thyroid hormones and normal thyroid function.

Magnesium helps to metabolise carbohydrates, fats, and proteins, contributes to the development and maintenance of bones and teeth, contributes to tissue formation, and contributes to the maintenance of normal muscle function.

Methylsulphonylmethane is used for joint health, a factor in maintaining joint health, and provides support for healthy joints, joint mobility, and joint comfort.

Potassium is a factor in the maintenance of good health.

Selenium is an antioxidant for the maintenance of good health.

Turmeric root extract is an antioxidant that helps to relieve inflammation.

Zinc helps in connective tissue formation, helps to maintain healthy skin, helps the body to metabolise carbohydrates, fats, and proteins, and helps to maintain immune function.

Why NALEO™ SPECTRUM?

Our Formulation

Delfran acknowledges the dynamic development of the brain and nervous systems. That’s why we’ve meticulously crafted this nutritional supplement with a combination of well-researched nutrients to support brain health together with healthy growth and development.

Our formulation distinguishes itself through its carefully curated ingredients, selected with our team of experts. In addition to providing essential vitamins and minerals for overall health and well-being, our formula boasts the following key ingredients:

Acetyl-L-carnitine:

Scientific investigations suggest that supplementing with L-carnitine could be advantageous in alleviating behavioral and cognitive symptoms among individuals with Autism Spectrum Disorder [1,2].

Choline:

Research highlights choline as an essential nutrient with a potential important role in promoting proper neurological and brain development [3].

Coenzyme Q10:

Coenzyme Q10 exhibits antioxidant properties, potentially offering neuroprotective effects that could be valuable in addressing neurodegenerative conditions [4].

Inositol:

Inositol potentially supports mood through its interaction with serotonin pathways. Recent studies propose the usefulness of serotonin reuptake inhibitors in addressing certain autism symptoms. Inositol, as a precursor to a second messenger for specific serotonin receptors, has been explored for its potential effectiveness in managing depression, panic disorder, and obsessive-compulsive disorder [5].

MSM:

Methylsulfonylmethane (MSM) may contribute to maintaining healthy inflammation levels within the body. This micronutrient is known to be well-tolerated and has been investigated for its potential benefits in addressing various conditions related to inflammation, physical function, and performance [6].

Folate:

Folate is a supporter of the development and functioning of a healthy nervous system, possibly influencing cognitive functions like learning and memory [7].

N-Acetyl L-Cysteine (NAC):

N-acetyl-L-cysteine may hold promise for addressing a range of psychiatric disorders, particularly in relation to negative symptoms of schizophrenia, severe autism spectrum disorder, OCD, and conditions linked to obsessive-compulsive tendencies [8,9].

Turmeric/Curcumin:

Curcumin, present in turmeric, functions as an antioxidant that supports appropriate inflammatory responses within the body. Multiple clinical trials have substantiated the potential efficacy of curcumin in addressing various neurodegenerative diseases [10].

Bioperine:

Bioperine, an extract from black pepper and a prominent bioactive compound, enhances nutrient absorption, potentially optimising the utilisation of various essential nutrients [11].

Other ingredients and possible benefits:

Vitamin A:

May be essential for brain function, especially in learning and memory. Deficiency in vitamin A could significantly impair cognitive abilities [12].

Vitamin B:

Neurotropic B vitamins may contribute to maintaining a healthy nervous system [13].

Vitamin C:

Deficiency in Vitamin C can directly impact brain function, particularly during developmental stages [14].

Vitamin D:

Individuals with ASD are prone to vitamin D deficiency, possibly due to environmental factors. Vitamin D3 deficiency has been linked to ASD symptoms [15].

Vitamin E:

Dietary supplementation of vitamins E and C might offer protection against neurodegenerative changes linked to cognitive impairment [16].

Vitamin H (Biotin):

Biotin treatment has shown improvements in verbal expression skills and learning performance among individuals with autism [17].

Vitamin K:

Recent studies highlight Vitamin K’s possible protective effects on neural cells and its role in maintaining normal neural development, including in cases related to autism [18].

Calcium:

Has shown to serve as a universal messenger for extracellular signals, possibly regulating neuronal functions and contributing to long-term processes like memory [19].

Chromium:

Supplementation with chromium may enhance cognitive control and cerebral function in individuals at risk for neurodegeneration [20].

Iodine:

Essential nutrient for thyroid hormone production, influencing brain development and cognitive function.

Cognitive impairments are one of the the main consequences of Iodine deficiency. This is revealed in the results of reading, spelling, and cognitive performance tests [21].

Magnesium:

Plays an important part for brain activity, with established relevance in preventing neurobehavioral diseases [22].

Selenium:

Selenium and selenoproteins have shown potential in slowing the progression of neurodegenerative disorders [23].

Zinc:

May be crucial for the development of the central nervous system, affecting the roles of proteins, enzymes, hormones, and growth factors that guide stem cell behavior in neurodevelopment [24].

Based on a study examining this vitamin/mineral supplement, it effectively addressed various nutritional and metabolic issues. Thus, incorporating vitamin/mineral therapy alongside other treatments like behaviour therapy and speech therapy appears to be a viable approach to assisting individuals with autism [25].

Choose NALEO™ SPECTRUM nutritional supplement for a comprehensive approach to nurturing your brain health and development.

References:

Kępka A, Ochocińska A, Chojnowska S, Borzym-Kluczyk M, Skorupa E, Knaś M, Waszkiewicz N. Potential Role of L-Carnitine in Autism Spectrum Disorder. J Clin Med. 2021 Mar 13;10(6):1202. doi: 10.3390/jcm10061202. PMID: 33805796; PMCID: PMC8000371.
Demarquoy, C. and Demarquoy, J., 2019. Autism and carnitine: A possible link. World journal of biological chemistry, 10(1), p.7.
Derbyshire E, Obeid R. Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days. Nutrients. 2020 Jun 10;12(6):1731. doi: 10.3390/nu12061731. PMID: 32531929; PMCID: PMC7352907.
Matthews, R.T., Yang, L., Browne, S., Baik, M. and Beal, M.F., 1998. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proceedings of the National Academy of Sciences, 95(15), pp.8892-8897.
Levine, J., Aviram, A., Holan, A. et al. Inositol treatment of autism. J. Neural Transmission 104, 307–310 (1997). https://doi.org/10.1007/BF01273191
Butawan M, Benjamin RL, Bloomer RJ. Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients. 2017 Mar 16;9(3):290. doi: 10.3390/nu9030290. PMID: 28300758; PMCID: PMC5372953.
Balashova, O.A., Visina, O. and Borodinsky, L.N., 2018. Folate action in nervous system development and disease. Developmental neurobiology, 78(4), pp.391-402.
Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, Frazier TW, Tirouvanziam R. A randomized controlled pilot trial of oral N-acetylcysteine in children with autism. Biol Psychiatry. 2012 Jun 1;71(11):956-61. doi: 10.1016/j.biopsych.2012.01.014. Epub 2012 Feb 18. PMID: 22342106; PMCID: PMC4914359
Bradlow, R.C., Berk, M., Kalivas, P.W., Back, S.E. and Kanaan, R.A., 2022. The potential of N-Acetyl-L-Cysteine (NAC) in the treatment of psychiatric disorders. CNS drugs, 36(5), pp.451-482.
10 Bhat, A., Mahalakshmi, A.M., Ray, B., Tuladhar, S., Hediyal, T.A., Manthiannem, E., Padamati, J., Chandra, R., Chidambaram, S.B. and Sakharkar, M.K., 2019. Benefits of curcumin in brain disorders. BioFactors, 45(5), pp.666-689.
11 Gohil, P. and Mehta, A., 2009. Molecular targets of pepper as bioavailability enhancer. Advances in Traditional Medicine, 9(4), pp.269-276.
12 Stoney, P.N. and McCaffery, P., 2016. A vitamin on the mind: new discoveries on control of the brain by vitamin A. Hidden Hunger, 115, pp.98-108.
Calderón‐Ospina, C.A. and Nava‐Mesa, M.O., 2020. B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS neuroscience & therapeutics, 26(1), pp.5-13.
Hansen, S.N., Tveden-Nyborg, P. and Lykkesfeldt, J., 2014. Does vitamin C deficiency affect cognitive development and function?. Nutrients, 6(9), pp.3818-3846.
Jia, F., Wang, B., Shan, L., Xu, Z., Staal, W.G. and Du, L., 2015. Core symptoms of autism improved after vitamin D supplementation. Pediatrics, 135(1), pp.e196-e198.
Martin, A., Youdim, K., Szprengiel, A., Shukitt-Hale, B. and Joseph, J., 2002. Roles of vitamins E and C on neurodegenerative diseases and cognitive performance. Nutrition Reviews, 60(10), pp.308-326.
Benke P.J., Duchowny M., McKnight D. Biotin and acetazolamide for treatment of an unusual child with autism plus lack of nail and hair growth. Pediatr. Neurol. 2018;79:61–64. doi: 10.1016/j.pediatrneurol.2017.10.013.
DeSoto, M.C., 2016. Speculations on vitamin K, VKORC1 genotype and autism. Medical Hypotheses, 96, pp.30-33.
Gareri P, Mattace R, Nava F, De Sarro G. Role of calcium in brain aging. Gen Pharmacol. 1995 Dec;26(8):1651-7. doi: 10.1016/0306-3623(95)00043-7. PMID: 8745152.
Krikorian R, Eliassen JC, Boespflug EL, Nash TA, Shidler MD. Improved cognitive-cerebral function in older adults with chromium supplementation. Nutr Neurosci. 2010 Jun;13(3):116-22. doi: 10.1179/147683010X12611460764084. PMID: 20423560.
Choudhry H, Nasrullah M. Iodine consumption and cognitive performance: Confirmation of adequate consumption. Food Sci Nutr. 2018 Jun 1;6(6):1341-1351. doi: 10.1002/fsn3.694. Erratum in: Food Sci Nutr. 2021 Jan 19;9(2):1256. PMID: 30258574; PMCID: PMC6145226.
Mousain-Bosc, M., Siatka, C. and Bali, J.P., 2018. Magnesium, hyperactivity and autism in children.
Pillai, R., Uyehara‐Lock, J.H. and Bellinger, F.P., 2014. Selenium and selenoprotein function in brain disorders. IUBMB life, 66(4), pp.229-239.
Gower-Winter SD, Levenson CW. Zinc in the central nervous system: From molecules to behavior. Biofactors. 2012 May-Jun;38(3):186-93. doi: 10.1002/biof.1012. Epub 2012 Mar 31. PMID: 22473811; PMCID: PMC3757551
Adams, J.B., Audhya, T., McDonough-Means, S., Rubin, R.A., Quig, D., Geis, E., Gehn, E., Loresto, M., Mitchell, J., Atwood, S. and Barnhouse, S., 2011. Effect of a vitamin/mineral supplement on children and adults with autism. BMC pediatrics, 11, pp.1-30.

Composition	Per serving
Methylsulphonylmethane (MSM)	1469 mg
Ascorbic acid (Vitamin C)	500 mg
Choline bitartrate providing Choline 250 mg	608mg
Acetyl-L-Carnitine	200 mg
DL-alpha-tocopheryl acetate providing Vitamin E 223.5 I.U.	165 mg
Magnesium citrate providing Magnesium 100 mg	620 mg
Inositol (Myo-inositol)	100 mg
Palatinose™ PST (isomaltulose)	100 mg
Calcium bisglycinate chelate providing Calcium 70 mg	500 mg
Potassium citrate providing Potassium 50 mg	140 mg
Turmeric root extract (95% curcuminoids)	50 mg
Coenzyme Q-10 (ubidecarenone)	50 mg
N-Acetyl-L-Cysteine (NAC) providing L-Cysteine 45 mg	61 mg
Riboflavin (Vitamin B2)	40 mg
Niacinamide (Vitamin B3)	35 mg
D-Calcium pantothenate providing Pantothenic Acid (Vitamin B5) 30 mg	66 mg
Thiamine mononitrate providing Thiamine (Vitamin B1) 20 mg	22 mg
Pyridoxine hydrochloride providing Pyridoxine (Vitamin B6) 20 mg	25 mg
Zinc oxide providing Zinc 15 mg	19 mg
BioPerine® (Piper nigrum (black pepper) [fruit extract])	2 mg
Vitamin A acetate providing Vitamin A 5000 I.U.	10mg
Manganese amino acid chelate providing Manganese 1 mg	10 mg
6S-5-Methyltetrahydrofolate Calcium providing Folate 500 µg	569 µg
D-Biotin (Vitamin H)	225 µg
Methylcobalamin (Vitamin B12)	100 µg
Potassium iodide providing Iodine100 µg Potassium 30 µg	130 µg
Ammonium heptamolybdate providing Molybdenum 100 µg	157 µg
Phytonadione (Vitamin K1)	80 µg
Chromium nicotinate providing Chromium 70 µg	700 µg
Selenium amino acid chelate providing Selenium 40 µg	2 mg
Menaquinone (Vitamin K2)	40 µg
Cholecalciferol providing Vitamin D 1000 I.U.	10 mg