a health supplement containing Inositols

METSYN X™

Are you facing challenges in maintaining a healthy weight despite following a balanced diet?

Do you find yourself losing weight on a high-protein diet but gaining it back when you return to a healthy eating plan?

Are you tired of struggling with stubborn belly fat?

Are you lacking energy throughout the day?

Do you experience cravings for sweet treats?

If any of these sound familiar, you may be dealing with Metabolic Syndrome, also known as Syndrome X.

Introducing METSYN X™, a health supplement formulated with Inositols.

Studies have shown that individuals with Metabolic Syndrome may benefit from Inositol supplementation (Myo-Inositol and D-Chiro-Inositol in a 40:1 ratio) [1].

Understanding the Role of Inositol

Myo-Inositol is a part of a secondary messenger system that may help regulate the body’s response to insulin, by ensuring that each cell receives the proper message from insulin, enabling glucose to enter the cells and be utilized as energy. On the other hand, D-Chiro Inositol may aid in storing any excess glucose within the cells as glycogen. This storage mechanism could help maintain normal blood glucose levels, even between meals, resulting in balanced insulin levels.

Myo-inositol and D-chiro-inositol are two naturally occurring forms of inositol, a type of sugar alcohol that plays a role in various cellular functions. They have been studied for their potential benefits in metabolic syndrome, a cluster of conditions that includes obesity, insulin resistance, high blood pressure, and dyslipidemia. There are some potential benefits of inositol on metabolic syndrome that have been observed. Here are a few of them:

Improved insulin sensitivity: Inositol may enhance insulin signaling and improve insulin sensitivity, which is beneficial for individuals with metabolic syndrome and insulin resistance. Studies have demonstrated that inositol supplementation, particularly a combination of myo-inositol and D-chiro-inositol in a specific ratio (40:1), may reduce insulin resistance and improve glucose metabolism in individuals with metabolic syndrome and polycystic ovary syndrome (PCOS) [2] [3].

Reduction in metabolic and cardiovascular risk factors: Inositol supplementation has been associated with possible improvements in various metabolic and cardiovascular risk factors commonly observed in metabolic syndrome. Studies have reported reductions in triglyceride levels, total cholesterol levels, and markers of inflammation (such as C-reactive protein) after inositol supplementation [4] [5].

Weight management: Inositol may also play a role in weight management, which is a crucial aspect of metabolic syndrome. Some research suggests that inositol supplementation may help regulate appetite, reduce food cravings, and contribute to weight loss in individuals with metabolic syndrome and PCOS [6] [7].

Unveiling Metabolic Syndrome

Metabolic Syndrome, also referred to as Syndrome X, is a cluster of risk factors that, when present together, increase the likelihood of developing cardiovascular diseases, diabetes, and strokes. These risk factors include obesity, excess abdominal fat, high blood pressure, insulin resistance, and abnormal cholesterol or triglyceride levels. While having one of these factors doesn’t necessarily mean you have Metabolic Syndrome, it does raise the risk of cardiovascular issues. The diagnosis of Metabolic Syndrome is made when a patient presents with three or more of these risk factors.

Diagnosing Metabolic Syndrome

To make a positive diagnosis of Metabolic Syndrome, at least three of the following factors need to be above normal ranges:

  • Waist circumference
  • Fasting triglyceride levels
  • Cholesterol levels
  • Blood pressure
  • Fasting glucose level

To determine these levels, consult with your physician for appropriate testing.

Complications OF Metabolic Syndrome

Metabolic Syndrome can lead to severe and chronic complications, including atherosclerosis, diabetes, heart attacks, kidney disease, strokes, non-alcoholic fatty liver disease, peripheral artery disease, cardiovascular disease, female infertility (Polycystic Ovarian Syndrome), and male infertility (decreased sperm quality).

It’s important to note that Metabolic Syndrome is prevalent in approximately 5% of people with a normal body weight, 22% of overweight individuals, and a staggering 60% of those considered obese. In international industrialized countries, around 20-30% of the population may be affected, and this figure may be even higher in the South African population.

Insulin Resistance:

In a healthy digestive system, insulin helps sugar (glucose) enter cells to be used as fuel. In cases of insulin resistance, cells do not respond normally to insulin, making it difficult for glucose to enter cells. Daily supplementation of Inositol’s (Myo- and D-Chiro Inositol) might prevent dietary deficiency of inositol and help rectify Inositol range required for normal glucose metabolism.

Obesity:

Excess fat in the abdominal area, known as central obesity or belly fat, poses a higher risk for cardiovascular disease compared to fat stored in other areas of the body. METSYN X™, enriched with Inositols, can positively impact glucose metabolism, which directly affects weight management and obesity.

Food Cravings:

Disrupted glucose metabolism can lead to intense food cravings. People often crave junk and processed foods high in sugar, salt, and fat. METSYN X™, containing Inositols, may help address the underlying causes of Metabolic Syndrome, including food cravings.

High Blood Sugar:

Proper blood sugar control is crucial for overall well-being. An imbalance in glucose levels can cause various symptoms such as headaches, excessive thirst, increased hunger, dry mouth, drowsiness, tiredness, and bloating. If you experience any changes in your day-to-day functioning, it’s essential to consult with your physician.

Low Energy Levels:

Despite having high glucose levels in the blood, cells may struggle to utilize glucose effectively if it cannot enter them. This can result in reduced energy levels and the storage of excess glucose as fat. METSYN X™ may help normalize this process, leading to increased energy levels.

  1. Costantino, D., et al. “Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial.” Eur Rev Med Pharmacol Sci 13.2 (2009): 105-110.
  2. Gerli, S., et al. (2007). Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. European Review for Medical and Pharmacological Sciences, 11(5), 347-354.
  3. Genazzani, A. D., et al. (2013). Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients. Gynecological Endocrinology, 29(4), 375-379.
  4. Santamaria, A., et al. (2016). Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trial. Journal of Maternal-Fetal & Neonatal Medicine, 29(19), 3234-3237.
  5. Costantino, D., et al. (2011). Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. European Review for Medical and Pharmacological Sciences, 15(5), 509-514.
  6. Carlomagno, G., et al. (2011). Myo-inositol in a new pharmaceutical form: a step forward to a broader clinical use. Expert Opinion on Drug Delivery, 8(8), 1047-1054.
  7. Colazingari, S., et al. (2018). Myo-inositol/D-chiro-inositol combined with folic acid in the treatment of metabolic syndrome in overweight subjects: comparison with a placebo plus folic acid supplement. Climacteric, 21(2), 132-138.

*It is recommended to consult with a healthcare professional before starting any new supplement or health regimen.

*This unregistered medicine has not been evaluated by the SAHPRA for its quality, safety or intended use.

Discover METSYN X™

All-in-one daily sachet.

Don’t let weight management challenges, low energy levels, food cravings, or high blood sugar hold you back from living your best life. Take charge of your metabolic health with METSYN X™.

  • Myo-Inositol    4 000 mg
  • D-chiro-inositol 100 mg

Dry, white powder packed in individual sachets. Each box contains 30 sachets.

Barcode: 6009801022376

NAPPI code: 723860001

Dosage and directions:
Dissolve one (1) sachet in a glass of water. Then drink the contents of the whole glass. Take one (1) sachet once daily, or as recommended by your healthcare provider.

Patient Information Leaflet