Female Hormone Imbalances

The following hormones play an important role in the cycle of a woman,

  • Estrogen
  • Follicle Stimulation hormone (FSH)
  • Luteinizing hormone (LH)

In order for a woman to fall pregnant, it is important that the female hormones are in balance. If one of the female hormones are imbalanced, the function or production of other hormones may be compromised.

It is also important to note that other hormones, for example insulin that is a metabolic hormone, may also influence the production of female hormones.

The production of female hormones works in a cycle and if any of the hormones is not produced or not regulated in sequence, the cycle is broken or disappears.
The production of estradiol in the ovaries is critical for the regulation and release of:

  • Follicle Stimulating Hormone (FSH) – remember FSH is responsible for the recruitment and development of follicles (bag in which eggs develop) and the oocytes (eggs).
  • Luteinizing hormone (LH) that is responsible for the release of a dominant egg during ovulation.

Without the regulation of estrogen, the brain will increase FSH and LH levels. An increase in the FSH levels will result in a number of follicles to develop but no egg may be released because the LH levels is higher than normal but does not peak to cause ovulation.
Woman is born with a fixed number of follicles (± 400 thousand). Several follicles will grow per month but normally only one dominant follicle will release its egg (ovulation).

After ovulation, the follicle that releases the egg will become a corpus luteum that produces progesterone to prepare the uterus for implantation (thickening of the endometrium) of the embryo. If ovulation does not take place, progesterone levels may not increase and there may be no menstruation phase because the endometrium did not develop.

The quality of all the follicles is not the same and several factors may have an influence on the normal development of the follicle and egg. Normally the best quality follicles will be used during the early reproductive stage and as the women gets older (above 35) , the number of follicles, and the quality of the follicles will decrease until none follicles are left (menopause).

Due to the imbalance of female hormones woman may struggle with an increase in the production of male hormaones which may result in acne, hursitism (unnatural hair development on females body) and/or Alopesia (loss of female body hair). The Ferriman-Gallwey hursitism score may be used to establish the excess of male hormones in female.

Metabolic Hormone Imbalances

A deficiency of Inositol may lead to increased levels of the hormone Insulin. Insulin is responsible for the absorption of glucose into cells. After eating a meal or sweet products, the level of glucose in the blood increase. The pancreas then releases Insulin to allow the glucose to enter the cells. On the outside of each cell you find a receptor (docking station) for the insulin. The insulin will lock onto the docking station and will send a message into the cell giving the cell permission to open specific ports to allow the glucose to enter.

Inositol is the main part of that secondary messenger that must convey the message from the receptor to the ports that needs to open. If there is an Inositol deficiency (shortage) then the insulin will dock onto the docking station send the message but the message will not be delivered to the ports. The ports therefore will remain closed and glucose will not enter the cells.

When a patient have high glucose levels the pancreas will notice the high glucose and will excrete more insulin, but the glucose can still not enter the cells. To ensure the body will have enough energy, the glucose will be stored as fat.

You will easily recognise those woman that may have a shortage of inositol because the majority of them will have the following symptoms:

  • Fat accumulates around the waist – typical apple shape body
  • Struggle to loose weight even on a good balanced diet and exercise
  • No energy (always tired) 
  • A crave for sweat things during meals.
  • No regular menstrual cycle or anovulation

Inofolic contains Myo-Inositol and restore the possible inositol imbalance to allow the reinstatement of the secondary messenger system within the cell to allow glucose to enter. The fact that the glucose can enter the cells will address the majority of problems experienced above.
Due to the imbalance of female hormones woman may struggle with acne and hursitism (unnatural hair development on females body) and Alopecia (loss of female body hair) see Ferriman-Gallwey_score