Supplement to support female patients during their menstrual cycle.


Introducing the all new and first of its kind, Dismeno.

You may experience premenstrual syndrome (PMS) symptoms before menstruation and /or experience pain or cramps in your pelvic area during menstruation (Dysmenorrhea). Dysmenorrhea may be mild, moderate or severe.  Dismeno capsules may improve your quality of life by maintaining a positive balance over unpleasant symptoms caused by PMS and/or Dysmenorrhea.

Dismeno is available over the counter at your local pharmacy or online stores

Dismeno contains 30 capsules per box

Each Dismeno capsule contains DLBS1442, a bioactive extract derived from Phaleria macrocarpa.

Recommended dose

The dosage is one capsule three times per day. It is recommended to start taking Dismeno capsules 3 days before commencement of menstruation until 3 days thereafter.  It is also recommended that the patient should use Dismeno capsules for a minimum of three months and may continue on a monthly basis thereafter.

The following symptoms should improve when treating PMS and/ or Dysmenorrhea successfully. A Visual Analog Scale (VAS) is used to measure the improvement of these symptoms.













It has been reported that 85% of women of reproductive age experience premenstrual syndrome which include emotional and physical symptoms during the days before menstruation starts. Three to eight percent of females experience disabling and severe symptoms that must be treated.

There are four types of PMS:

  1. Type A (anxiety) characterised by anxiety, sensitivity and moody behavior
  2. Type C (craving) characterised by desire of sweets, fatigue, increased heart rate, dizziness and in severe cases fainting.
  3. Type D (drama, aggression & depression) characterised by loss of confidence, oversensitive, feeling weak, forgetfulness, easily distracted, sleep disorder and communication problems.
  4. Type H (water balance) characterised by edema, flatulence, breast pain, swelling of the feet and hands as well as gaining weight before menstrual period.

It is critical to treat PMS due to the degree of stress and incapacity it may cause which directly has an effect on the quality of life of females. To treat PMS effectively, treatment should start at least 10 days before menses. Symptoms usually become less severe at the onset of menstruation or shortly afterwards.

Unfortunately some females will also start to experience cramping pains in the lower abdomen (Dysmenorrhea) before or with the onset of menstruation


Dysmenorrhea is the medical term for cramping pains in the lower abdomen just before or during menses which are caused by uterine contractions. Most women experience these cramps as discomfort, although some can be so severe that it has a debilitating effect on day-to-day life.

Dysmenorrhea can be divided into primary and secondary dysmenorrhea.


Primary dysmenorrhea is menstrual pain that is not associated with any physical abnormalities (such as endometriosis) within the pelvic region and it usually affects women in their reproductive years.  The reported prevalence of primary dysmenorrhea is very high at about 90% of adolescent females and is often underdiagnosed and undertreated in these patients. These patients usually have higher endometrial prostaglandins (which are involved in inflammation and blood flow) which result in stronger and more frequent uterine contractions resulting in moderate to severe abdominal pain.

Pain is usually described as sharp, intermittent spasms usually centred in the pelvic area or lower back. Other symptoms experienced may include nausea, vomiting, diarrhoea, fatigue, fever, headache or light-headedness. Onset of pain is usually 1-3 days before menstruation starts, peaking on day 1 or 2 of menstruation after which it usually subsides.


Secondary dysmenorrhea is menstrual pain that is associated with anatomic or macroscopic pelvic pathology (such as endometriosis or chronic pelvic inflammatory disease) and it usually affects women aged 30-45 years.

Secondary dysmenorrhea is usually diagnosed by a physician because it is more complicated and there are many possible tests and laboratory results that need to be considered.


Treatment will depend on the causes and symptoms experienced by the patient. PMS and dysmenorrhea may be caused by several factors that include hormonal and/or hormonal receptor (specific site where hormones will attach/bind to achieve a specific effect) imbalances, overstimulation of inflammation precursors, specific growth factors and immunity response factors.

The majority of female patients use lifestyle changes and drugs, for example Non-Steroidal Anti-inflammatory drugs (NSAID’s) which may address the inflammation (PGE2) and uterine contraction (PGF2A) symptoms of PMS and/or dysmenorrhea. Unfortunately up to 30% of patients develop gastrointestinal side effects associated with NSAID’s and 18% of patients remain resistant to NSAID treatment.  NSAID’s also do not address other possible causes of PMS or dysmenorrhea.

Delfran is proud to announce the launch of Dismeno capsules that may assist you when experiencing unwanted symptoms1 during your menstrual cycle.

Available at your nearest pharmacy or online.


Dismeno contains 30 capsules per box.

Delfran is proud to announce the launch of Dismeno capsules that may assist you when experiencing unwanted symptoms during your menstrual cycle.


For more information on Dismeno please send an email to or phone our offices at +27 12 543 3029


  1. Tjandrawinata et al. 2011. Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea with DLBS1442, a bioactive extract of Phaleria macrocarpa. International Journal of General Medicine.

This unregistered medicine has not been evaluated by the SAHPRA for its quality, safety or intended use.

Page last updated: 06-04-2020